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One presymptomatic mutation-carrier showed a DWI lesion, another an acute asymptomatic, and no cSAH was observed

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Downstream Cascade A — NAD+ Salvage and SIRT1 Activation NNMT normally acts as a “sink” for nicotinamide, permanently removing it from the NAD+ salvage pathway by methylating it into 1-MNA (which is then excreted)