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237 Type 2 cytokines and T-helper 2 (Th2) inflammatory responses promote fibrosis by activating the Transforming growth factor β (TGF-β) signaling pathway, 238 which is responsible for activation of fibroblasts to produce ECM and collagens, and for fibroblast-to-myofibroblast differentiation
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As a general rule, IV therapy can be safely administered 1-2 times per week, allowing the body adequate time to process the treatment and avoid overloading the system
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