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Activated STAT1 enhances NF-κB signaling, which drives additional pro-inflammatory cytokine release, activates caspases-3 and -9, upregulates iNOS, and boosts nitric oxide production-culminating in cellular scorching and irreversible hearing loss ( via CB2 receptor engagement-exerts a counterbalancing, cytoprotective effect ( 3.3 Regulatory role of TRP channels in cochlear hair cells TRP channels form an intricate and finely tuned regulatory network within the cochlea
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