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Epigenetic regulation of specific genes by HDACs through impairment of histone acetylation has been attributed to PD, accomplished through inhibitors of HDACs whose effects could lead to increased histone acetylation and transcription of genes that encode specific neurotrophic factors or via a reduction in the accumulation of neurotoxic proteins (such as α-synuclein) causing a neuroprotective effect (Shukla and Tekwani, 2020)
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