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While no association was found between acetaminophen (even when taken in high doses or for long periods of time) and most types of cancer, some studies suggested that acetaminophen could increase risk for renal cell carcinoma, a type of kidney cancer
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Several mechanisms have been reported as responsible for cisplatin resistance, such as reduced drug uptake by a decrease in CTR1 expression, increased efflux by ABC transporters, augmented induction of stress response chaperones, induction of autophagy, inactivation of apoptosis pathway signaling, inactivation by thiol-containing proteins, and functional changes in DNA repair pathways 6,7,8,9,10,11
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