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Some biomarkers, for example the accumulation of phospho-tau proteins, or the decrease in Aβ42 levels in the CSF, serve as excellent diagnostic markers but may be less valuable as evaluation tools for therapeutic development

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Thymic B cells requiring in vitro stimulation to produce autoantibodies are likely memory B cell populations, which require additional signals in order to differentiate to an antibody-secreting cell (ASC) phenotype (37, 38)