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The optimum pH for the GR was 7.0 (Figure 5A), and the optimum temperature was 30°C (Figure 5B)
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The IL-17 secreted by these cells binds to IL-17 receptors (IL-17Rs) expressed in midbrain neurons, inducing neuronal death through the upregulation of NF-κB and downstream signaling pathways, as demonstrated in human iPSC-derived neuronal models
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