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Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40
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Human research suggests glutathione supplementation may improve glutathione status and support antioxidant defenses, though questions remain regarding the relative absorption of different formulations.60 61 62 Liposomal products have become particularly popular because they may improve bioavailability.63 For a deeper dive into the science and our favorite products, see our guide to the best glutathione supplements
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