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Increased mitochondrial ROS appears to be a common mediator, linking increased glucose metabolism via the polyol pathway, accumulation of advanced glycation end products (AGEs), protein kinase C (PKC) activation, and increased activity of the hexosamine pathway with vascular damage in diabetes [179]
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[DOI] [PubMed] [Google Scholar] 176.Agarwal PK, Sadetsky N, Konety BR, Resnick MI, Carroll PR, Cancer of the Prostate Strategic Urological Research Endeavor (CaPSURE) Investigators Treatment failure after primary and salvage therapy for prostate cancer
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