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However, despite extensive investigations into transcriptional networks, signaling pathways, and cellular interactions, the precise molecular mechanisms, including the contribution of metabolism and free radicals, driving lineage diversification from foregut endoderm, particularly in hPSC differentiation, remain incompletely characterized
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PUFAs can be converted to PUFA-containing phospholipids (PUFA-PLs) by ACSL4 and LPCAT3, which then react with ROS utilizing iron as a catalyst, thus triggering lipid peroxidation and ferroptosis [5, 12, 13]
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