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In rat brain microvascular endothelial cells under an oxygen- and glucose-deprivation environment (OGD), that mimics ischemic stroke in vitro, DHA was shown to decrease apoptosis, COX-2 protein expression, and the secretion of PGE 2 , PGI 2 , vascular endothelial growth factor (VEGF), and angiopoietin-2 (Ang-2, which has been shown to cause blood–brain barrier damage and to increase endothelial cell apoptosis) [123]
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