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Some of the upregulated pathways in ARIH2 and CCNC KO NK cells were cytokine receptor interaction, IFN response, and IL signaling pathways
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In 2018, the Nomenclature Committee on Cell Death (NCCD) defined ferroptosis as “a form of regulatory cell death initiated by oxidative perturbations of the intracellular microenvironment that is under constitutive control by glutathione peroxidase 4 (GPX4) and can be inhibited by iron chelators and lipophilic antioxidants” (Galluzzi et al., 2018)
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