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Precision medicine involves tailoring treatment plans to individual patient characteristics, such as genetic profiles, comorbidities, and lifestyle factors [107]
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Figure 6 ).40 The attractive in vitro/in vivo pharmacology and pharmacokinetic attributes of 1 were offset by its S-9/NADPH-dependent genotoxic effects in the bacterial Salmonella Ames assay, which led to its discontinuation from clinical development
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