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A myostatin-selective inhibitor for use in treating obesity or in improving body composition in a subject, wherein the treatment comprises administering to the subject the myostatin-selective inhibitor in conjunction with a GLP-1 receptor agonist and a biguanide, wherein the myostatin-selective inhibitor, the GLP-1 receptor agonist, and the biguanide, are administered in effective amounts to treat obesity or improve body composition
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