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Mass Spectrometry for Adductomic Analysis | Frontiers Research Topic
Summary Keywords nicotinamide N-methyltransferase (NNMT), metabolic syndrome (MetS), nicotinamide adenine dinucleotide (NAD + ), homocysteine (Hcy), obesity, diabetes, hyperlipidemia, hypertension Citation Sun W-D, Zhu X-J, Li J-J, Mei Y-Z, Li W-S and Li J-H (2024) Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome
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We used a unique chemistry approach to tune the reactivity of our molecule, so that we’re targeting what would typically be considered a bad biomarker.” The researchers tuned the dynamic range of the molecule so that it would not react to glutathione under healthy conditions but would react with the excess glutathione made by cancer cells
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