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In the brain, CBS is also the major enzyme catalyzing the production of hydrogen sulfide (H 2 S) from L-cysteine (Kimura, 2011) or from the condensation of homocysteine with cysteine ( 2 S is now considered as a major gasotransmitter in the brain, which plays a role in synaptic transmission (Kamat et al., 2015) and its increased production resulting from CBS triplication has been suggested to contribute to the cognitive phenotype of DS patients (Kamoun, 2001
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