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However, in the complex molecular processes that characterize tumorigenesis, iron also plays a central role in ferroptosis, a form of non-apoptotic regulated cell death characterized by the lethal accumulation of lipid peroxidation products and ROS derived from iron metabolism (362, 363)
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Sufficient clinical evidence is available to recommend the use of NAC or carbocisteine as an addition to current therapies in certain patients with COPD, at least in the hope of reducing the number of respiratory exacerbations and possibly improving the health-related quality of life
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