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In high-fat diet animal models, increased expression of the ROS-generating enzyme NADPH oxidase 4 and the ROS product 3-nitrotyrosine (3-NT) at the ocular surface in addition to increased apoptosis, which destabilizes the corneal epithelial barrier function, also induces abnormalities in lacrimal gland lipid accumulation, inflammation, lipid peroxidation, and apoptosis, resulting in decreased tear secretion, which leads to DED [35,74]
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Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
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