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The thioredoxin (TXN) system, a disulfide reductase system, is another major antioxidant system in mammalian cells, maintaining a reducing environment by mediating the transfer of electrons from reduced nicotinamide adenine dinucleotide phosphate (NADPH) via TXN reductase to TXN, which subsequently uses highly conserved vicinal thiol groups to reduce its target proteins [56]
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