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In the first study, 32 patients with refractory IC/BPS were given intravesical instillation of heparin-lidocaine (20,000 units heparin, 5 mL 4% alkalized lidocaine, 25 mL 7% sodium bicarbonate) weekly for 12 weeks
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Also, as discussed above and in the following sections, GPx-1 can regulate apoptogen-mediated signaling in apoptosis (404), alter the activation of NFκB (205, 224), and modulate Akt pathways (154, 351) to affect cellular proliferation and survival, suggesting that GPx-1 may have pleiotropic effects on apoptotic susceptibility
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