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The parent Tβ4 protein forms a 1:1 complex with G-actin and prevents its polymerization into F-actin filaments (Safer, Elzinga & Nachmias, 1991), and Tβ4 binding measurably alters monomer conformation and dynamics (De La Cruz et al., 2000)
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To meet this, it seems crucial for any therapeutic approach to consider and effectively apply the three-to-one ratio (Figure 6): three competence-orientated areas of health-related actions, including—first and foremost—the prevention of diseases, maintenance of good health status, and promotion of health, followed by one, as a last resort, medicalized therapeutic strategies (as a fourth area of competence-orientated actions) to target specific health conditions, including curing and healing diseases
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