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Acquired 5-oxoprolinemia results from longstanding depletion of glutathione and cysteine stores that occurs due to malnutrition, sepsis, and chronic acetaminophen use (6)
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The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)
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