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The most important biological mediators in the pathogenesis of PD are as follows: reactive oxygen species (ROS), reactive nitrogen species (RNS), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), transforming growth factor beta-1 (TGF-ß1), platelet-derived growth factor (PDGF), interleukin-1 (IL-1), basic fibroblast growth factor (bFGF), plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor-alpha (TNF-α)
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Consistently, EVs from DXR-treated MG63 presented with higher levels of both the ABCB1 transcript and P-gp-encoded protein expression, which can be transferred to untreated MG63 cells, conferring their drug resistance (158)
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