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Anemia implies widespread effects from blood that either is too scarce (e.g., blood loss) or is dysfunctional in its oxygen-supplying ability (due to whatever type of hemoglobin or erythrocyte problem)

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Upon collision-induced dissociation (CID), these oxidized linkages fragment more productively, producing more assignable backbone fragments from each peptide, including link-site-containing fragments, thereby improving peptide identification, residue-pair assignment, and crosslink scores 47,48