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By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance (80)
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Through coordinated phagocytosis, antigen presentation, cytokine secretion and crosstalk with immune and non-immune cells, macrophages play a central role in regulating inflammatory responses, host defense and tissue homeostasis
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