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His214 (depending on its tautomeric state, see below) may establish a hydrogen bond with Cys215 carbonyl, an interaction which has been suggested to increase the partial charge on the backbone nitrogen enhancing its reactivity and supporting a nucleophilic substitution mechanism for PTP1B[87,88]
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Hypermobility in Ehlers–Danlos syndrome Eye Thin cornea, with or without rupture Blue sclera Keratoconus — the cornea has a cone-like shape Keratoglobus — the globular protrusion and thinning of the cornea See more images of Ehlers–Danlos syndrome
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