glutathione transferases a structural perspective X-ray structure of S-transferase from the malarial parasite Plasmodium falciparum Gst enzyme

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The S protein with a pre-fusion conformation is usually metastable and easily transformed into the post-fusion conformation

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Moreover, the findings that mice with neutrophil-specific Gpx4 haploinsufficiency recapitulate key clinical features of human SLE, including autoantibodies, neutropenia, skin lesions and proteinuria, and that the treatment with a specific ferroptosis inhibitor significantly ameliorates disease severity in lupus-prone mice reveal the role of neutrophil ferroptosis in lupus pathogenesis