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Cancer cells are characterized by persistent self-replication, destruction of normal structures and high cytosolic catalytic Fe 2+ [493]
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The almost 2-fold greater reduction in liver fat with efruxifermin than with FGFR1-selective BFKB8488A is consistent with this argument, as FGFR1c agonism would mainly reduce steatosis by suppressing adipose tissue lipolysis
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