glutathione hydroxyl radical The redox system and its related metabolism. (A) Methanol Gsh

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It plays a crucial role in neutralizing various reactive molecules, including hydroxyl radicals (*OH), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and other oxidative byproducts produced by phagocytes 39,40

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Moreover, studies indicate that enhanced BCAA metabolism boosts the activity of antioxidant enzymes, such as glutathione, helping tumor cells resist treatment-related accumulation of reactive oxygen species (ROS) ( in vitro and to radiation both in vivo and in vitro ( 3.3 Interaction with glucose and lipid metabolism The cross-regulation between BCAA metabolism and glucose and lipid metabolism plays a crucial role in metabolic reprogramming within tumor cells