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While Lys147 monoubiquitylation of GDP-bound K-RAS significantly enhances the affinity to CRAF (more than 40-fold), monoubiquitylated GTP-bound K-RAS shows attenuated binding affinity for the RAS binding domain of certain RAS effectors (CRAF, RALGDS, and PI3Ks) (Thurman et al., 2017)
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10.1074/jbc.M305063200 10.1074/jbc.M305063200 [DOI] [PubMed] [Google Scholar] Stancill JS, Broniowska KA, Oleson BJ, Naatz A, Corbett JA (2019) Pancreatic β-cells detoxify H2O2 through the peroxiredoxin/thioredoxin antioxidant system
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