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The biopsies were divided into approximately four explant-sized pieces, and were then transferred into 0.25% w v −1 trypsin solution (Gibco Biocult, UK) containing 10 mg ml −1 collagenase type IV (Sigma, USA) and incubated for 30 min at 37°C
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This activation triggers downstream signaling pathways, leading to the phosphorylation of STAT proteins, thereby regulating the expression of a series of genes and affecting cell function and physiological activity
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