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Rat preparations of gastric ulceration, NSAID-induced gastrointestinal lesions, intestinal anastomosis, and inflammatory bowel injury have been the most frequently used models, beginning with the Sikirić group's 1993 foundational characterization [8]
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Indeed, the response of B cells through anti-CII immunoglobulin is predominantly by Immunoglobulin G2 (IgG2) to trigger a complementary cascade, which is a vital phase for the development of CIA
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