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Specialty Testing Clinical Laboratory | Doctor's Data

Th1 cytokines increase epithelial permeability which in turn will increase the passage of gluten peptides and peptide binding to DQ2 and DQ8 molecules on antigen-presenting cells, leading to a chronic feedback of the inflammatory process as long as gluten peptides are present in the intestinal lumen (Figure 1)

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Total IgG, IgG1, IgG2 and IgA antibodies coupled with IFN-γ and IL-2 expression in peripheral blood mononuclear cells, splenocytes and lymph node cells, but no IgG3 and IgG4 were elicited in either group, indicative of a mixed/balanced Th1/Th17 and Th2 response (39)