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Enzymatic demethylation of 7,8-dihydromethysticin followed by ring opening of the alpha-pyrone ring, and rearrangement was suggested to contribute to the formation of highly GSH reactive metabolite 6-phenyl-3-hexen-2-one as its mercapturic acid adduct found in human urine [43]
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This provides a mechanistic link between environmental factors (e.g., Western diet) and the control of inflammation at the level of innate immune cells
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