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Loop 3 provides the necessary flexibility in the ABS of the bacterial GUSs to accommodate various substrates According to the enzyme-activity analysis, all GUSs accepted one or more substrates larger than 10 , but the superimpositions of Cp GUS and Rg GUS with the Bifd GUS E479A / 10 complex indicated possible steric clashes between the aglycone and loop 5 or loop 3 of Cp GUS and Rg GUS, respectively
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