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In the kidney, these genes were induced with B 12 supplementation, likely a feedback response caused by the large influx of B 12 storage into the kidney after supplementation (Extended Data Fig
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PI3K Inhibitor Reversed the Effect of Dihexa in the Brains of APP/PS1 Mice To validate whether the PI3K/AKT signaling pathway is involved in the mechanism of the Dihexa, we detected the number of neuronal cells and the level of SYP and inflammatory factors in the brains of mice after intragastric administration of wortmannin (a PI3K inhibitor)
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