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Moreover, increased purine/pyrimidine metabolism probably supports not only energy production, but also antioxidant synthesis 37 , and possibly neuroprotection 38,39
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4) Integrate multi-disciplinary approaches for clinical translation: Combine artificial intelligence (AI)-driven drug discovery (e.g., machine learning models to predict ferroptosis modulator efficacy using multi-omics data) with network pharmacology to identify synergistic drug combinations (e.g., ferroptosis inhibitors + anti-fibrotic agents)
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