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The aforementioned inflammatory mediators further activate T cells and mast cells, initiating a self-perpetuating loop that leads to excessive keratinocyte proliferation, neutrophil recruitment, vascular proliferation and persistent skin inflammation [33]
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In particular, malondialdehyde (MDA) and 4-hydroxy-2-nonenal are end products of lipid peroxidation, and oxidative and carbonyl stress lead to the permanent production of oxidation products, such as advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs), due to the conversion of excess metabolites such as glucose and lipids
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