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These secretions block the exocrine movement of the digestive enzymes into the duodenum and result in irreversible damage to the pancreas, often with painful inflammation (pancreatitis)

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Fracture non-union often results in devastating outcomes for the patient and the surgeon [2, 5, 6], requiring a complex, long-lasting and expensive treatment, and a variable degree of morbidity is often a common finding [2, 7, 8]