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AO 12 LNPs shield mRNA from oxidative degradation To systematically evaluate the protective capacity of AO N LNPs against oxidative degradation, we exposed mRNA-loaded nanoparticles to physiologically relevant reactive species, including superoxide anion (O 2 - ·), hydroxyl radical (·OH), hydrogen peroxide (H 2 O 2 ), hypochlorite (ClO - ), and peroxynitrite (ONOO - ), which were generated using well-established chemical systems to mimic the oxidative microenvironment of injured tissue
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