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When to Contact Your Provider A nodule is not a normal depot response, and you should stop injecting at that site and call your prescribing provider the same day, if any of the following applies: pain that is increasing rather than fading over the first 24 to 48 hours redness that is spreading outward from the site, or a red streak tracking away from it the area is warm or hot to the touch fever, chills, or feeling systemically unwell any drainage, pus or fluid from the site the nodule is growing rather than shrinking, or is still present beyond two to three days hives, widespread itching, swelling of the face or lips, or any difficulty breathing, which is an emergency and warrants immediate care rather than a phone call These signs may indicate infection, an immune reaction to the preparation, or a reaction to peptide-related impurities, and all of them require clinical evaluation

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