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It was observed that in spite Hg compounds target Trx reductase at low concentrations (1 μM) due to the low pKa selenol in its active site [175,176], Trx functionality was kept until Hg levels were above 5 μM
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We then investigated the accessibility of glutathione by treating hepatocytes on the two culturing ECMs with a cytotoxin, 4-hydroxynonenal (4-HNE)
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