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Renal insufficiency, indicated by serum creatinine levels of 1.5 mg/dL or higher in men and 1.4 mg/dL or higher in women, is a contraindication for metformin therapy
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These metabolites are absorbed in the small intestine, bind to serum albumin, and are transported to the liver, where they undergo sulfation, glucuronidation, and methylation to form stable metabolites, which are then distributed throughout the body (Figure 3) (Manach et al., 1995
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