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Bevacizumab was the first anti-angiogenic drug used in patients with RCC, followed by VEGFR inhibitors such as sunitinib, sorafenib, pazopanib, cabozantinib, and axitinib (101)

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However, there was an increase in compressive stiffness (Figure 6N) in p14BAPN mice but not tensile stiffness or range of motion (Figures 6O and 6P), which combined with reduced DHI suggests the collapse and compaction of the IVD, consistent with the histological findings showing the degradation of the AF layers

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