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Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling

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"Silencing inhibitory neurons in a hunger-promoting brain region creates a functional brake on appetite, a mechanism distinct from simple satiety signaling." This finding suggests tesofensine's appetite effects go beyond monoamine elevation and involve direct modulation of hypothalamic circuitry