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Based on their amino acid sequence homology, the main CYP isozymes that are involved in the metabolism of drugs are arranged into three gene families (CYP1, CYP2 and CYP3) ( Genetic polymorphism and mutations of CYP genes including CYP1A1, CYP2A6, CYP2A13, CYP2C8/9/19, CYP2D6, CYP2B6 and CYP3A4 ( Stress impact on CYP-catalyzed drug metabolism Various external and internal factors can modify the regulation of most CYP genes
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