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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
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Taken together, integrative analyses show that these three loci modulate MASLD risk via different biological pathways: PNPLA3 via lipid droplet remodeling, TM6SF2 via impairment of hepatic lipid export, and MBOAT7 via membrane phospholipid turnover [278]
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