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The phosphorylation of S409/410 on the TDP-43 CTD was identified in patients with TDP-43-induced frontotemporal lobar degeneration (FTLD), as well as highly consistent features in pathologic inclusions 87
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Specifically, this was marked by increased IL-6 production, heightened neutrophil infiltration, and exacerbated liver injury, indicating that iron dysregulation in CD11c + myeloid cells plays a pivotal role in the progression of acute liver injury
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