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34 In addition to proton influx channels, transmembrane protein 175 (TMEM175) has been identified as a lysosomal proton efflux channel
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Mice with EAE had elevated CNS levels of another molecular indicator of lipid peroxidation, 4-hydroxynonenal (4-HNE), along with MDA, whereas detoxification of these reactive aldehydes ameliorated the disease [15]
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