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Retatrutide alone has the strongest direct evidence: TRIUMPH-4 (December 2025): 28.7% weight loss at 68 weeks at 12mg TRIUMPH-1 (May 2026): 25.0% at 80 weeks, 30.3% at 104 weeks at 12mg TRIUMPH-2 and TRIUMPH-3 (July 2026): Both confirmed positive topline results For CagriReta specifically — cagrilintide combined with retatrutide — no Phase 3 data has been published
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